Calicut is well connected to major cities in India by Air, Rail and Road.

The Calicut International Airport is located at Karipur, 25 Kms. south-east of the city. Tourist taxi charges about Rs 400 from airport to Calicut town. Regular flights are available to Mumbai, Bangalore, Chennai, Goa, Madurai, and Coimbatore. The nearby airports are Cochin, Coimbatore and Mangalore.

Direct trains are available from Calicut to the major cities in India which include New Delhi, Mumbai, Kolkata, Hyderabad, Bangalore, Chennai, Gowhatti, Ahmedabad, Indore, Gorakhpur, Trichy, Mangalore, Varanasi, Jammu Tawi and Trivandrum. The Calicut bound trains take deviation from the main Chennai-Cochin route from Palghat Junction.

By road, Calicut is connected to Mumbai via Mangalore and Goa (NH17). Bangalore is connected via Mysore, Gundalpet Sultan Bathery, Kalpetta and Mysore (NH 212). Chennai is via Malappuram, Palghat, Coimbatore and Salem (NH 213 and NH47), and Ooty is via Nilambur and Gudalur (State Highway). The connection to Kanyakumari is via Cochin and Trivandrum (NH17 and NH47).